Mevalonic acid ( MVA) is a key organic compound in biochemistry; the name is a contraction of dihydroxymethylvalerolactone. The carboxylate anion of mevalonic acid, which is the predominant form in biological environments, is known as mevalonate and is of major pharmaceutical importance. Drugs like statins (which lower levels of cholesterol) stop the production of mevalonate by inhibiting HMG-CoA reductase.
Chemistry
Mevalonic acid is very soluble in water and polar organic solvents. It exists in equilibrium with its
lactone form, called
mevalonolactone, that is formed by internal condensation of its terminal alcohol and
carboxylic acid . Mevalonolactone acts to correct statin linked myopathy and limb girdle muscular disease caused by HMG CoA reductase mutation.
Biology
Mevalonic acid is a precursor in the biosynthetic pathway known as the mevalonate pathway that produces
and
. Mevalonic acid is the primary precursor of isopentenyl pyrophosphate (IPP), that is in turn the basis for all terpenoids. Mevalonic acid is chiral and the (3
R)-
enantiomer is the only one that is biologically active.
See also
-
Fructilactobacillus fructivorans
-
Sake
